IL-32 alpha Protein 3040-IL-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-32 alpha Protein
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number3040-IL-050
SpeciesHuman
Molecule NameIL-32 alpha
Quantity50 ug
NCBI Full Gene Nameinterleukin 32
NCBI Gene AliasesIL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd
FormatLyophilized from a 0.2 µm filtered solution in PBS and DTT
Purity>85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 18.8 kDa, reducing conditions
Theoretical: 14.9 kDa
Brand/TrademarkR&D Systems, a Bio-Techne Brand
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human IL-32 alpha Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairsScientific reportsFebruary 17, 2023Garofano K, Rashid K, Smith M, Brantner C, Suwunnakorn S, Diemert D, Gordon O, Horvath A, Khan S, Popratiloff A, et al.

(2) Dienogest May Reduce Estradiol- and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture- and Mouse Model-Based StudyBiomedicinesNovember 21, 2022Kim HJ, Kim SH, Oh YS, Lee SR, Chae HD.

(3) IL-32 Supports the Survival of Malignant T Cells in Cutaneous T-cell LymphomaJournal of Investigative DermatologyAugust 1, 2022Kenneth K. Yu, Neal P. Smith, Sernah V. Essien, Jessica E. Teague, Pablo Vieyra-Garcia, Ahmed Gehad, Qian Zhan, Jack D. Crouch, Nega Gerard, Cecilia Larocca, et al.96-well plates in the presence or absence of IL-2 (25 IU/mL, NCI), IL-32α (25 ng/mL, R&D Systems, #3040-IL-050), IL-32β (25 ng/mL, R&D Systems, #6769-IL-025), or IL-32γ (25 ng/mL, R&D Systems, #4690-IL-025/CF).

(4) On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine stormCell reportsMarch 8, 2022Conod A, Silvano M, Ruiz I Altaba A.

(5) Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical AtherosclerosisFrontiers in ImmunologyApril 15, 2021Mohamed El-Far et al.Monocytes with purity >95% were stimulated with 500 ng/ml of IL-32 isoforms α, β, or γ (R&D Systems Cat # 3040-IL-050, 6769-IL-025, 4690-IL-025/CF, respectively) in RPMI medium supplemented with 10% FBS. Supernatant of

(6) IL-32 exacerbates adenoid hypertrophy via activating NLRP3-mediated cell pyroptosis, which promotes inflammationMolecular medicine reportsMarch 1, 2021Zhang J, Sun X, Zhong L, Shen B.

(7) IL-32γ potentiates tumor immunity in melanomaJCI insightSeptember 17, 2020Gruber T, Kremenovic M, Sadozai H, Rombini N, Baeriswyl L, Maibach F, Modlin RL, Gilliet M, von Werdt D, Hunger RE, et al.

(8) Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1Science advancesFebruary 1, 2018Palstra RJ, de Crignis E, Röling MD, van Staveren T, Kan TW, van Ijcken W, Mueller YM, Katsikis PD, Mahmoudi T.

(9) Dendritic Cell-Derived IL-32α: A Novel Inhibitory Cytokine of NK Cell FunctionJournal of immunology (Baltimore, Md. : 1950)August 15, 2017Gorvel L, Korenfeld D, Tung T, Klechevsky E.

(10) Increased Interleukin-32 Levels in Obesity Promote Adipose Tissue Inflammation and Extracellular Matrix Remodeling: Effect of Weight LossDiabetesDecember 1, 2016Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Valentí V, Moncada R, Landecho MF, Silva C, Salvador J, Frühbeck G.

(11) Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway BlockadeClinical cancer research : an official journal of the American Association for Cancer ResearchSeptember 1, 2015Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, Xu H, Meeker AK, Fan J, Cheadle C, et al.

(12) M-CSF inhibits anti-HIV-1 activity of IL-32, but they enhance M2-like phenotypes of macrophagesJournal of immunology (Baltimore, Md. : 1950)June 1, 2014Osman A, Bhuyan F, Hashimoto M, Nasser H, Maekawa T, Suzu S.

(13) Molecular mechanisms regulating the synergism between IL-32γ and NOD for the activation of eosinophilsJournal of leukocyte biologyApril 1, 2014Wong CK, Dong J, Lam CW.

(14) Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitorsNatureJuly 26, 2012Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, et al.

(15) Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritisProceedings of the National Academy of Sciences of the United States of AmericaMarch 22, 2011Heinhuis B, Koenders MI, van de Loo FA, Netea MG, van den Berg WB, Joosten LA.

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IL-32 alpha Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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IL-32 alpha Protein from R&D Systems, a Bio-Techne Brand

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